Autoimmune Disorders

Insulin dependent Diabetes (Type-1) model

• Non-Obese Diabetic (NOD Mice)

Multiple sclerosis

• Experimental Autoimmune Encephelomyelitis (EAE): a Multiple sclerosis
• MOG (myelin-oligodendrocyte-glycoprotein) Induced
• PLP (proteolipid protein) Induced

Rheumatoid Arthritis Models

• Collagen Induced Arthritis (CIA)
• Type-2 Collagen Monoclonal Antibody (mAB) Cocktail

Adoptive transfer model

• Passive Transfer of Sensitized Lymphoid Cells

Lupus models

Lupus is a complex heterogeneous disease characterised by autoantibody production and immune complex deposition followed by damage to target tissues. Animal models of human diseases are an invaluable tool for defining pathogenic mechanisms and testing of novel therapeutic agents. The spontaneous models of lupus provided important insight into the complex genetics of lupus. A number of strains of mice develop a lupus-like disease following pristane injection. B6 mice, when injected with pristane, develop low-grade autoimmunity, but also develop pulmonary vasculitis and pulmonary haemorrhage, yielding a valuable animal model for studying this rare, but devastating complication of lupus.

A more recently developed mouse model for lupus used resiquimod cream administered to the ears of specific strains of mice.71 72 This cream, containing a TLR7 ligand, is in human use in management of pre-cancerous skin lesions. When repeatedly rubbed onto the ears of BALB/c mice and limited other strains, a lupus-like disease develops in 2–4 weeks with autoantibody production, splenomegaly and immune complex glomerulonephritis. The mice exhibit, as expected, heightened levels of type I IFN activity.

Inflammation

Allotransplantation

• Skin Transplantation – Host Immune Response to Foreign Tissue (Murine Allograft)

Local Inflammation models

Dermal Inflammation

• Dermal Scar Model
• Skin Inflammation
• Dermal 2,4-Dinitro-1-Fluorobenzene (DNFB)
• Intradermal Methylated-BSA

Hepatitis

• Non-Lethal LPS/D-GalN Induced Hepatitis (Acute Model)

Inflammatory Bowel Disease (IBD)

• Dextran Sodium Sulfate in Drinking Water (DSS)
• Colonic Instillation of Trinitrobenzene Sulfonic Acid (TNBD)
• IL-10 knockout model

Peritonitis

Sepsis

• Intraperitoneal Lipopolysaccharide (LPS)
• Intraperitoneal Staphlococcal Enterotoxin-B (SEB)

Fibrosis

Dermal fibrosis – bleomycin induced